CAR-T Cell Therapy Market By Targeted Antigen (CD 19, Pipeline Therapy Analysis), By Indication (Non-Hodgkin’s Lymphoma, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia) - Growth, Share, Opportunities & Competitive Analysis, 2018 – 2026
Industry Outlook
The CAR-T cell therapy market was valued at US$ 72.0 Mn in 2017 and projected to exhibit double digit compound annual growth rate (CAGR) of 51.1% during the forecast period from 2018 to 2026. Scientist have encountered the biggest challenge in the treatment of cancer is that the cancer cells with the disease progression usually become invisible to the body’s defense mechanism. Immunotherapy is the future in the treatment of cancer where the immune cells are genetically engineered in order to recognize the biomarkers of cancerous cells, target them and kill them. CAR-T cells therapy do not kill the normal healthy cells and has proven effective in relapsed cancer treatment. The CAR-T cell therapy market is driven by factors such as rising prevalence of cancer, growing research in the immune-oncology, and massive funding from government health institution and pharma giants in CAR-T cell therapy development. The traditional approach adopted for the treatment of leukemia was blood transfusion to increase the count of healthy blood cells, antibiotics used to curb the spread of infection and chemotherapy to kill the leukemia cells present in the bone marrow. However, advances in the cell therapy and gene therapy has have rendered the development of oncology treatment by body’s own immune system. The FDA approved CAR-T cell therapy are Axicabtagene ciloleucel (Yescarta) and Tisagenleucel (Kymriah),). Currently CD19 antigens have been approved by USFDA for the treatment of relapsed b-cell acute lymphocytic leukemia. Whereas, there are more than 2,000 candidates in the clinical trials for different cancer indications.
Growing Research and Development of CAR-T to Drive the Market Growth
CD 19 antigens are currently studied extensively to prove its efficacy in the treatment of acute lymphoblastic leukemia. Rising prevalence of acute lymphoblastic leukemia in children and adults has buttressed the dominance of CD 19 antigens to be utilized for cancer therapy. Yescarta (axicabtagene ciloleucel), and Kymriah (tisagenlecleucel) are the two approved CD19 therapies and the only CAR-T cell therapies currently approved in the market. CD 22 and CD 30 antigens are being studied diligently in the preclinical trials with promising results for the treatment of B cell acute lymphoblastic leukemia and non-Hodgkin’s lymphoma respectively.
Rising Prevalence of Blood Cancers to Augment the Growth of CAR-T Cell Therapy Market
The non-Hodgkin’s lymphoma segment dominated the market in 2017 owing to a surge in the number of NHL cases coupled with the higher adoption of YESCARTA (axicabtagene ciloleucel) and Kymriah (tisagenlecleucel, formerly CTL019) around the world. CAR T cell therapy products are currently indicated in non-Hodgkin’s lymphoma, acute lymphocytic leukemia, and chronic lymphocytic leukemia only. However, clinical trials of some CAR T cell therapy drugs being studied (under study) for the treatment of multiple myeloma, acute myeloid leukemia, melanoma, glioblastomas, myelodysplastic syndromes (MDS), and cancer of pancreatitis, prostate, bladder, esophagus, stomach, liver, lung, kidney, & cervix. Thus, proliferating application of CAR-T in various indication would further boost the market during the forecast period.
Increasing Adoption of CAR-T Cell Therapy in North America will Drive Swift Growth during the Forecast Period
In 2017, North America demonstrates supremacy in the global CAR-T cell therapy market owing to the exclusive availability of the two approved products Kymriah (Novartis AG) and Yescarta (Gilead Sciences, Inc.). Developed healthcare infrastructure, high accessibility to advanced therapies, rise in healthcare expenditure, incessant investment in R&D activities, and presence of established market leaders further catalyzes the overall market growth in this region. With Medicare constantly working on structuring suitable reimbursement policies for dynamically priced CAR-T cell therapies, the demand for it is projected to increase during the forecast period. In Asia Pacific, the market entry of Kymriah expected by end of 2018 in Japan. The extensive pipeline portfolio for CAR-T cell therapy in China and the continuous growing cancer prevalence in Asia Pacific regions predominantly contribute to the maximum growth.
Historical & Forecast Period
2016 – Historical Year
2017 – Base Year
2018-2026 – Forecast Period
This research report presents the analysis of each segment from 2016 to 2026 considering 2017 as the base year for the research. Compounded annual growth rate (CAGR) for each respective segments calculated for the forecast period from 2018 to 2026.
Report Scope by Segments
CAR-T cell therapy market report furnishes quantitative analysis along with its latest market trends. The market is segmented based on antigen type, indication and geography.
By Antigen Type (2016–2026; US$ Mn)
- CD 19
- Pipeline Analysis (Qualitative Analysis)
- CD 20
- CD 22
- CD 30
- CD 33
- GD 2
- HER 2
- MESO
- EGFRvIII
By Indication (2016–2026; US$ Mn)
- Non-Hodgkin’s Lymphoma
- Acute Lymphocytic Leukemia
- Chronic Lymphocytic Leukemia
Geography Segment (2016–2026; US$ Mn)
- North America
- U.S.
- Canada
- Europe
- U.K.
- Germany
- Rest of Europe
- Asia Pacific (APAC)
- China
- Japan
- Rest of APAC
- Latin America (LATAM)
- Brazil
- Mexico
- Rest of Latin America
- Middle East and Africa (MEA)
- GCC
- Rest of Middle East and Africa
Market is studied in order to understand the current and future market trends in the CAR-T cell therapy market. The market is estimated by providing the compounded annual growth rate (CAGR) and data forecast from 2018 to 2026. Strategic acquisition, merger and collaboration among the key players for developing innovative product pipeline mentioned in the business strategy section. The key players currently engaged in the CAR-T cell therapy market are Bellicum Pharmaceuticals, Inc., Immune Therapeutics, Celgene Corporation, Juno Therapeutics, Cellectis, Eureka Therapeutics, Kite Pharma, Sorrento Therapeutics and Novartis AG, Gilead Sciences among others.
Key questions answered in this report
- How the global CAR-T cell therapy market will perform during the forecast period from 2018 to 2026?
- What are the latest trends in the CAR-T cell therapy market and valuable opportunities for key players?
- Who are the leading players in the global CAR-T cell therapy market?
- Which is the leading/and fastest region in the global CAR-T cell therapy market?
- Currently, what are the reimbursement scenario and regulatory structure for the CAR-T cell therapy?
- What are drivers and restrains governing the global CAR-T cell therapy market?
- What is the pipeline scenario of the global CAR-T cell therapy market?
- Which indications are being targeted using CAR-T cell therapy?
- What is the status of the clinical trials studied for various antigens?
Chapter 1 Preface
1.1 Report Description
1.1.1 Study Purpose
1.1.2 Target Audience
1.1.3 USP and Key Offerings
1.2 Research Scope
1.3 Research Methodology
1.3.1 Phase I – Secondary Research
1.3.2 Phase II – Primary Research
1.3.3 Phase III – Expert Panel Review
1.3.4 Assumptions
Chapter 2 Executive Summary
2.1 Global CAR-T Cell Therapy Market Portraiture
2.2 Global CAR-T Cell Therapy Market, by Indication, 2017 vs 2026 (Value %)
2.3 Global CAR-T Cell Therapy Market, by Geography, 2017 vs 2026 (Value %)
Chapter 3 Global CAR-T Cell Therapy Market: Dynamics and Future Outlook
3.1 Overview
3.2 Market Drivers
3.2.1 Emerging Immuno-Oncology in Clinical Cancer Research
3.2.2 Rising Prevalence of Cancer
3.3 Challenges
3.3.1 High Cost of CAR-T Cell Therapy
3.4 Opportunities
3.4.1 Mergers and Acquisition in the CAR-T Cell Therapy Market
3.4.2 CAR-T Cell Therapy Beyond Cancer Treatment
3.5 Attractive Investment Proposition: Global CAR-T Cell Therapy Market, by Indication, 2018
3.6 Competitive Analysis: Global CAR-T Cell Therapy Market, 2017
Chapter 4 Global CAR T Cell Therapy Market, by Targeted Antigen, 2017-2026 (US$ Mn)
4.1 Overview
4.1.1 Global CAR T Cell Therapy Market, by Targeted Antigen, 2017 – 2026 (US$ Mn)
4.1.2 CD 19
4.2 Pipeline Therapy Analysis
4.2.1 CD 20
4.2.2 CD 22
4.2.3 CD 30
4.2.4 CD 33
4.2.5 GD 2
4.2.6 HER 2
4.2.7 MESO
4.2.8 EGFRvIII
4.2.9 Major Clinical-stage CAR-T projects with commercial licensees
Chapter 5 Global CAR T Cell Therapy Market, by Indication, 2017-2026 (US$ Mn)
5.1 Overview
5.2 Non-Hodgkin’s Lymphoma
5.3 Acute Lymphocytic Leukemia
5.4 Chronic Lymphocytic Leukemia
Chapter 6 Global CAR-T cell Therapy Market, by Geography, 2017 – 2026 (US$ Mn)
6.1 Overview
6.1.1 Global CAR-T cell Therapy Market, by Geography, 2017 – 2026 (US$ Mn)
6.2 North America
6.2.1 North America CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.2.2 North America CAR-T cell Therapy Market, by Country, 2017 – 2026 (US$ Mn)
6.2.2.1 U.S. CAR-T cell Therapy Market, 2017 – 2026 (US$ Mn)
6.2.2.2 Canada CAR-T cell Therapy Market
6.3 Europe
6.3.1 Europe CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.3.2 Europe CAR-T cell Therapy Market, by Country/Region, 2017 – 2026 (US$ Mn)
6.3.2.1 United Kingdom CAR-T cell Therapy Market
6.3.2.2 Germany CAR-T cell Therapy Market
6.3.2.3 Rest of Europe CAR-T cell Therapy Market
6.4 Asia Pacific
6.4.1 Asia Pacific CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.4.2 Asia Pacific CAR-T cell Therapy Market, by Country/Region, 2017 – 2026 (US$ Mn)
6.4.2.1 Japan CAR-T cell Therapy Market
6.4.2.2 China CAR-T cell Therapy Market
6.4.2.3 Rest of Asia Pacific CAR-T cell Therapy Market
6.5 Rest of World
6.5.1 Latin America
6.5.2 Latin America CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.5.2.1 Mexico CAR-T cell Therapy Market
6.5.2.2 Brazil CAR-T cell Therapy Market
6.5.2.3 Rest of Latin America CAR-T cell Therapy Market
6.5.3 Middle East & Africa
6.5.4 Middle East & Africa CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
Chapter 7 Company Profiles
7.1 Bellicum Pharmaceuticals, Inc.
7.2 Celgene Corporation
7.3 Cellectis
7.4 Eureka Therapeutics, Inc.
7.5 Immune Therapeutics, Inc.
7.6 Gilead Sciences, Inc.
7.7 Novartis AG
7.8 Sorrento Therapeutics, Inc.
TABLE 1 Key Strategic Partnerships in CAR-T Cell Therapy Development
TABLE 2 Global CAR T Cell Therapy Market, by Targeted Antigen, 2017 – 2026 (US$ Mn)
TABLE 3 Global CAR T Cell Therapy Market, by Indication, 2017–2026 (US$ Mn)
TABLE 4 Drugs Categorization, by Indication
TABLE 4 Global CAR-T cell Therapy Market, by Geography, 2017 – 2026 (US$ Mn)
TABLE 5 North America CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
TABLE 6 North America CAR-T cell Therapy Market, by Country, 2017 – 2026 (US$ Mn)
TABLE 7 Europe CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
TABLE 8 Europe CAR-T cell Therapy Market, by Country/Region, 2017 – 2026 (US$ Mn)
TABLE 9 Asia Pacific CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
TABLE 10 Asia Pacific CAR-T cell Therapy Market, by Country/Region, 2017 – 2026 (US$ Mn)
TABLE 11 Latin America CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
TABLE 12 Middle East & Africa CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
TABLE 13 Bellicum Pharmaceuticals, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 14 Celgene Corporation: Company Snapshot (Business Description; Financial Performance; Product Portfolio; News Coverage)
TABLE 15 Cellectis: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 16 Eureka Therapeutics, Inc.: Company Snapshot (Business Description; Financial Performance; Product Portfolio; News Coverage)
TABLE 17 Immune Therapeutics, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 18 Gilead Sciences, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 19 Novartis AG: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
TABLE 20 Sorrento Therapeutics, Inc.: Company Snapshot (Business Description; Financial Information; Product Portfolio; Key Developments)
FIG. 1 Global CAR-T cell Therapy Market: Research Methodology
FIG. 2 Global CAR-T cell Therapy Market, by Indication, 2017 vs 2026 (Value %)
FIG. 3 Global CAR-T cell Therapy Market, by Geography, 2017 vs 2026 (Value %)
FIG. 4 Attractive Investment Proposition: Global CAR-T cell Therapy Market, by Indication, 2016
FIG. 5 Competitive Analysis: Global CAR-T cell Therapy Market, 2016
FIG. 6 Global CD 19 Market for CAR T Cell Therapy, 2017 – 2026 (US$ Mn)
FIG. 7 Non-Hodgkin’s Lymphoma Market for CAR T Cell Therapy, 2017–2026 (US$ Mn)
FIG. 8 Acute Lymphocytic Leukemia Market for CAR T Cell Therapy, 2017–2026 (US$ Mn)
FIG. 9 Chronic Lymphocytic Leukemia Market for CAR T Cell Therapy, 2017–2026 (US$ Mn)
FIG. 10 U.S. CAR-T cell Therapy Market, 2017 – 2026 (US$ Mn)
FIG. 11 Canada CAR-T cell Therapy Market, 2017 – 2026 (US$ Mn)
FIG. 12 United Kingdom CAR-T cell Therapy Market, 2018 – 2026 (US$ Mn)
FIG. 13 Germany CAR-T cell Therapy Market, 2018 – 2026 (US$ Mn)
FIG. 14 Rest of Europe CAR-T cell Therapy Market, 2018 – 2026 (US$ Mn)
FIG. 15 Japan CAR-T cell Therapy Market, 2019 – 2026 (US$ Mn)
FIG. 16 China CAR-T cell Therapy Market, 2019 – 2026 (US$ Mn)
FIG. 17 Rest of Asia Pacific CAR-T cell Therapy Market, 2019 – 2026 (US$ Mn)
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