Surging Growth In Gene Therapy Research Fostering Gene Synthesis Market
Gene synthesis market offering artificial genes as a solution for utilization in synthetic biology applications such as research, therapeutics, diagnostics holds lucrative growth opportunities in the market. Global gene synthesis market is expected to show a growth rate of 17.4% during the forecast year 2019-2026. Owing to increasing incidence of genetic disorders (specifically rare diseases, monogenic diseases and congenital anomalies), the demand for gene synthesis application in gene-based therapies and diagnostics can be confidently expected to surge. Synthetic gene synthesis offers a novel approach for the creation of therapeutic antigens and antibody engineering, DNA vaccines, etc. and to understand the biological pathway that is essential in gene and immunotherapy-based research. For instance, according to the UK based Global Genes, a non-profit organization, the prevalence of rare diseases accounts to about 350 million cases globally as of year 2019 and about 1 in 10 people are affected by rare diseases.
Furthermore, according to WHO report 2016, due to congenital anomalies per year, about 303,000 new-borns die within 4 weeks of birth worldwide. These anomalies are commonly found among resource constrained families and countries; low income families can be treated as an indirect determinant. As per the World Health Organization, approximately 94% of severe congenital anomalies occur in middle and low-income countries, where mothers (women) suffer from malnutrition and have increased exposure to factors like infection, drugs and alcohol which increases the chances of abnormal prenatal development. Increased maternal age also heightens the risk of chromosomal abnormalities like down syndrome. The same risk also increases during young maternal age. As per Genetic Disorders UK, genetic disorders affect 30,000 children and babies every year in UK. Rising number of genetic diseases has resulted in the diversion of research towards the development of therapies, thereby increasing the demand for gene synthesis.
Moreover, advent of innovative genetic editing technologies such as CRISPR cas9, ZFN etc. has lowered the cost of genomic editing thereby making the therapy-based research process sophisticated for researchers across the globe.
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Gene synthesis bringing a paradigmatic shift in the process of drug discovery
The genetic technology-based drug discovery model focuses on those research areas which are related to the development and discovery of new therapeutic entities with the help of genomic editing. Gene synthesis services such as mutagenesis library services and high throughput gene synthesis offers gene screening capabilities at an accelerated pace for the purpose of drug discovery. Rising drug trials and approvals has boosted the demand for these services. For instance, as per the article published on gene therapy clinical trial worldwide at National Centre for Biotechnology Information, as of year 2018, about 2600 gene therapy clinical trials have been completed, approved or are ongoing globally. Moreover, as per US Food and Drug Administration, total number of drug approvals by CDER (Centre for Drug Evaluation and Research) has seen a growth from 24 in the year 2008 to 46 in the year 2017. Increasing drug trials have directly influenced the market growth of gene synthesis services across the global market.